Quantitation of renal plasma flow with stage progress of essential hypertension using 99mTc-MAG3
نویسندگان
چکیده
منابع مشابه
Synthesis, formulation and quality control of 99mTc-MAG3, as a renal tubular 99mTc-radiopharmaceutical kit [Persian]
Radionuclidic techniques may provide assessment of glomerular filtration rate (GFR) effective renal plasma flow (ERPF) or individual renal function. Several agents were available for determination of these parameters such as ¹³¹I-OIH (O-iodohippurate) and different derivatives of DADS (Diamidodisulfur). OIH has the disadvantage of imparting a relatively high absorbed radiation dose to the...
متن کاملAssessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy
BACKGROUND Renal scintigraphy using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) is widely used for the assessment of renal function in humans. However, the application of this method to animal models of renal disease is currently limited, especially in rodents. Here, we have applied 99mTc-MAG3 renal scintigraphy to a mouse model of unilateral ureteral obstruction (UUO) and evaluated its utility...
متن کاملOff-site determinations of effective renal plasma flow using technetium-99m-MAG3 and single blood sampling.
UNLABELLED This study evaluated the feasibility of determining effective renal plasma flow (ERPF) at an off-site central laboratory by transferring blood samples from the on-site laboratory. METHODS Blood samples were obtained from 66 patients referred for renal imaging with 99mTc-MAG3. ERPF values were determined using the single blood sample method (BSM) at both on- and off-site laboratorie...
متن کامل99mTc-MAG3: review of pharmacokinetics, clinical application to renal diseases and quantification of renal function.
About 14 years have passed since Fritzberg et al. developed 99mTc-MAG3 in 1986. The biological properties of this radiopharmaceutical are somewhat different from radioiodine labeled hippurate: it exhibits higher protein binding, slower blood clearance, higher extraction efficiency by tubular cells and larger excretion into the bile than the latter. Nonetheless, it has been widely used as the ag...
متن کاملRenal haemodynamics and plasma renin in patients with essential hypertension.
1. Blood pressure, glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured in twenty-three patients with essential hypertension and in twenty-one control subjects. Plasma renin concentration was measured in all the hypertensive patients and in fifteen control subjects. 2. GFR and RPF were similar in the hypertensive group and in the control group, whereas the renal vascular r...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1999
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(99)80368-9